Abstract: A case of plasma cell vulvitis is reported.A 60-year-old woman patient presented with recurrent erythema and erosion in the vulva for 9 months.She complained of an recurrence and aggravation of the lesions for 1 month.Physical examination revealed dusky-red macules with moist surface,scattered white pseudomembrane-like erosion on both labias,and extensive hypertrophy of the clitoris.Histologic examination showed that there was a diffuse infiltration with inflammatory cells in upper to middle dermis, most of which were mature plasma cells,and a few extravasating erythrocytes.The clinical manifestations and pathological findings supported the diagnosis of plasma cell vulvitis,which was recalcitrant to treatment. Repeated intralesional injections ofbetamethasone complex solution(diprospan)and interferon alpha resulted in short-term improvement of the disease.

Key words: Plasma cells, Vulvitis, Female