Chinese Journal of Dermatology

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mRNA expression of cyclooxygenase-2 and vascular endothelial growth factor in patients with squamous cell carcinoma

ZHAI Ning1, GUAN Chao2, LI Jiu-hong1, LIU Wei3, HAN Xiu-ping1, GENG Long1, SONG Fang-ji1, CHEN Hong-duo1   

  1. Key Laboratory of Immunodermatology, Ministry of Public Health, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2005-09-26 Online:2006-04-15 Published:2006-04-15

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Abstract: Objective To investigate the mRNA expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in skin tissue of squamous cell carcinoma (SCC) and normal skin tissue,and the relationship between the expression of COX-2 and VEGF.Methods The rnRNA expression of COX-2 and VEGF was measured by reverse transcription-polymerase chain reaction(RT-PCR) in skin specimens from 24 cases of SCC and 10 normal controls.Results The mRNA expression of COX-2 was higher in SCC specimens than in control skin (0.56±0.48 vs.0.01±0.01,P<0.05).The mRNA expression of VEGF was significantly higher in SCC specimens than in normal skin tissue (0.66±0.35 vs 0.02±0.01,P<0.05).And the expression of COX-2 was associated (γ=0.864) with the expression of VEGF.Conclusion COX-2 may be related to the angiogenesis in SCC,and likely to play its role by up-regulation of VEGF expression.

Key words: Carcinoma, squamous, Prostaglandin-endoperoxide synthase, Vascular endothelial growth factors, Gene expression