Abstract: Objective To report a case of entomophthoromycosis caused by Conidiobolus coronams.Methods Other tumorous diseases were ruled out in this patient by the history and a series of clinical and laboratory evaluations of the nose,including X-ray,computed tomographic(CT),magnetic resonance imaging(MRI)and endoscopic examinations.Biopsy and fungal culture of the lesion were performed.The effect of the treatment was also evaluated.Results The histopathological examination of the specimen taken with nasal endoscope showed eosinophilic granuloma,as well as transverse hyphae(surrounded by eosinophilic material,i.e.Splendore-Hoeppli phenomena)with thin and broad wall in multinucleated giant cells.Ejected sporangioles developed satelite colonies in fungal culture of tissue,especially in potato medium,which could be seen through the cover of flat plates.Microscopic examination showed coccoid sporangia with pyramidal papilla,ascus crowns developed by numerous sporangiola,and villose sporangiolum.Resolution of the pruritus and flattening of the lesions were seen after one week of treatment with potassium iodide 10% solution(20～30 mL tid)and SMZ-SD-TMP.Conclusions This is the first report ofentomophthoromycosis caused by Conidiobolus coronatus in China.Conclusion therapy with potassium iodide and SMZ-SD-TMP is effective for this condition.

Key words: Zygomycosis, Conidiobolus