Abstract: Objective To observe the clinical efficacy and safety of ultrapulse CO₂ laser-assisted autologous epidermal grafting for the treatment of vitiligo.Methods 1605 patients with 30660 skin grafts were treated by CO₂ laser-assisted autologous epidermal grafting.Among them,782 patients had localized vitiligo,319 segmental,226 general and 278 scattered.Epidermal grafts were harvested with negative pressure blistering method from normally pigmented skin,and recipient areas were prepared with a ultrapulse CO₂ laser.The curative effect was evaluated 8 weeks later.Results 79.04% of the lesions were cured completely,and total response rate was 92.21%,with better effect in localized and scattered lesions than in other lesions.The best results were shown in face,while the worst results shown in brow and hairline lesions.Conclusions The advantage of combined therapy of CO₂ laser with autologous epidermal grafting in vitiligo is of easy performance,convenience,high response rate,which is worthy of large scale application.

Key words: Vitiligo, Transplantation, Lasers