Abstract: Objective To assess the clinical efficacy and safety of benzoyl peroxide gel(BPG)with different concentrations in the treatment of acne vulgaris,and to compare the quality between the domestic products with imported products.Methods The study was an open-controlled clinical trial.The patients were divided into4groups:imported 2.5%,5%,10% gel and domestic 5% gel.All preparations were applied twice daily for6weeks.Study visits took place at baseline and week 2,4 and 6.Results Different concentrations of benzoyl peroxide gel were effective for inflammatory lesions.The longer the course of treatment and the higher the drug concentration were,the better global clinical efficacy was,and the optimum concentration was 5% or 10%.In addition,the higher the drug concentration was,the higher adverse reaction rate was.Transient and mild local skin irritation occurred but was well tolerated by the patients.The imported benzoyl peroxide 5% gel was as effective as domestic benzoyl peroxide 5% gel,but the adverse reaction rate was less than the latter.Conclusion Different concentrations of benzoyl peroxide gel are all effective and safe in the treatment of acne vulgaris,with the optimum concertration is 5% or 10%.

Key words: Benzoyl peroxide gel, Acne vulgaris, Open-controlled clinical trial