Abstract: Objective To evaluate the clinical efficacy and safety of adapalene 0.1% gel with individualized treatment regimen for acne vulgaris(ITRAV).Methods Eighty-one patients with acne vulgaris of mild to moderate severity were treated with adapalene 0.1% gel topically1to 3 times daily for 6 to 8 weeks according to the severity of the disease.Clinical responses were recorded and photographed weekly in 30 patients randomly selected from the 81 patients,and treatment regimens were adjusted accordingly.Results It was shown that cure rates were 44.4% and 73.4%,in 81 recruited cases and 30 selected cases,respectively.Seborrhea decreased remarkably(83.3%) in the treatment.Side effects took place in 39.5% of patients without interruption of the treatment.Conclusions ITRAV with adapalene 0.1% gel has been proved to have an excellent response.Reasonably increasing the daily dosage could improve the cure rates.The cutaneous tolerability of the drug was generally good.Seborrhea could be reduced considerably during the treatment.

Key words: Acne vulgaris, Adapalene