Chinese Journal of Dermatology ›› 2003, Vol. 36 ›› Issue (1): 38-40.

Previous Articles     Next Articles

Expression of IFN-γmRNA and IL-10mRNA on Peripheral Blood Mmononuclear Cells of Patients With Pemphigus

LUO Xiao-qun1, JIN Yan1, LI Feng1, XU Song-li2, FU Hai-jun3, WENG Meng-wu1   

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2002-02-28 Online:2003-01-15 Published:2003-01-15

PDF (PC)

102

Like

Abstract: Objective To probe the Th cytokine pattern in pemphigus,so as to clarify the pathogenesis of pemphigus and draw up new therapy.Methods Reverse transcription-polymerase chain reaction(RT-PCR)was used to examine the interferon gamma(IFN-γ)and interleukin 10(IL-10)mRNA expression on peripheral blood mononuclear cells(PBMCs)of 20 cases of pemphigus in acute stage,20 cases in stable stage,and 20 normal controls.Results The IFN-γmRNA expression in 20 cases of pemphigus in acute stage was higher than that of controls(P<0.001),while in stable stage there was no difference with that of controls(P=0.98).IL-10mRNA expression of pemphigus in acute stage was lower than that of controls,but the difference was not significant(P=0.0834).Conclusion IFN-γmRNA expression is predominant in acute stage of pemphigus.

Key words: Pemphigus, Interferon typeⅡ, Interleukin-10, RNA,messenger