Abstract:

Objective To investigate the relationship between Sjögren's synd rome and associated other skin diseases. Methods Clinical features, laboratory a nd histopathological findings and causes were analyzed retrospectively in 13 cas es of Sjögren's syndrome. Results Thirteen patients were studied, including 1 male and 12 female, the meanage of onset was 35.3 years old. All 13 cases prese nted features of xerostomia and xerophthalmia. The diagnosis was confirmed by positive Schirmer's test, corneal fluorescein staining, and sialography. The associated other dermatoses were verruca planae, pemphigus, lichen planus, vitiligo, herpes zoster, herpes simplex and systemic lupuserythematosus. All cases were treated with Chinese traditional and western medicines. Twelve cases improved markedly, one eventually died of liver and renal failure and circulation failure. Conclusions The pathogenesis of Sjögren syndrome maybe linked to autoimmunity, and immunological aberration has been implicated in most of associated skin diseases. The intrinsic relationship between Sjögren syndrome and associated other dermatoses needs further investigation.

Key words: Sjögren’s syndrome, Skin diseases