Abstract:

Objective To observe the efficacy of Botulinum toxin type A(BTXA)injection in Meige's syndrome and facial wrinkles and explore the method of reducing the side effect of BTXA and weaken facial wrinkles.Methods Ninety-nine patients were evaluated on the therapeutic efficacy of single and multiple topical facial injection with BTXA.Results The effective rates of patients with blepharospasm were 98.4%,oromandi bular dystonia 90.9%,blepharospasm and oromandibular dystonia 95.8%,respectively.The therapeutic effect for each disease lasted(16.9±8.4)weeks、(12.6±5.4)weeks and(13.5±5.7)weeks,respectively.Facial wrinkles of all patients has got weakened and seemed much smooth and flattend.The recovery rate approached to 100%.The local side effects were transient and mild,and disappeared spontaneously.Conclusions The treatment of Meige's syndrome and facial wrinkles with BTXA could produce a significant improvement,and is safe.Strictly observe the procedures of injection,and use adequate dose of BTXA,the side effects of BTXA can be decreased.

Key words: Botulinum toxin type A, Meige’s syndrome, Skin aging