Abstract: Objective To construct a murine model of vaginal candidiasis.Methods A kind of pseu-doestrus(estrogen-treated)mice was inoculated with 5×10⁴ stationary-phase blastoconidia of Candida albicans in-travaginally,and the vaginal lavage fluid and vaginal tissues were obtained at day 2,4,7,14 and 21 after inoculation.Results Compared with non-estrogen-treated mice,there was high load of C.albicans in the culture of lavage fluid from the second day to the twenty-first^t day after inoculation;Vaginal tiss sue from C.albicans-inoculated mice contained large amount of hyphae in the superficial mucosa.Conclusion This animal model of C.albicans vaginitis provides a means to study the pathogenesis of mucosal C.albicans infections.

Key words: Candida albicans, Candidiasis,vulvovaginal, Disea se models,animal