Abstract: Objective To investigate the association betw een systemic lupus erythematosus(SLE)and polymorphismof Fc gamma receptor ty peⅢin Han patients fromHunan province.Methods Genotypes of FcγRⅢa-158V/F were determined by polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)analysis in 65 patients with SLE and 60normal controls.Results ①It was found that the frequency of homozygous FcγRⅢa-158F/F genotype was significantly h igher in patients with SLE than that i n controls(OR=2.23,χ²=4.69,P=0.03).②The frequencies of both homozygous FcγRⅢa-158F/F genotype and FcγRⅢa-158F allele were significantly high er in patients with lupus nephritisc ompared with those in controls(OR=2.67,χ²=5.36,P=0.02;OR=2.00,χ²=4.91,P=0.03).Conclusions These results suggest that an abnorm al distribution of FcγRⅢa-158V/F polymorphism is associated with SLE in the Hans of Hunan province,and the presence of FcγRⅢa-158F allele is a risk factor for lupus nephritis.These findings support the hypothesis of a genetic mechanism in the pathogenesis of SLE.

Key words: Lupus erythematosus,systemic, Receptors,IgG, Immunoglobulin allotypes