Abstract: Objective To report the first case of disseminated trichosporonosis in China.Methods A series of clinical,histopathologic,and mycologic studies were carried out in a 20 year-old-female patient,who had no definite underlying disease.The causative fungus was identified according to culture,biochemical test and DNA sequencing.Results Abundant fungal spores,yeasts and hyphae were shown in the specimens taken from infectious granulomas.The fungal colonies in the culture of skin lesions or crusts,liver, oral psedomembrane,vagina,nasal cavity,urine,and stool were the same.The colonies exhibited creamy white to yellowish in color,rugose on the surface,and hyphae at the periphery.Under microscopy,there were a lot of rectangular arthrospores,round or oval spores with or without buddings,as well as branched and septate filaments.The isolated fungus was unanimously identified as Trichosporon asahii(No. AS 2.2174) through culture,biochemistry and molecular biology tests.The patient's condition was improved obviously after the combination treatment of amphotericin B liposome(Amphotec) and fluconazole.Conclusion The extensive and lasting systemic impairments caused by T. asahii have scarcely been reported at home and abroad.Combination therapy with amphotericin B and fluconazole is effective.

Key words: Trichosporon, Trichosporonosis