Abstract: Objective To investigate the association of erythema multiforme(EM) with HLA. Methods ClassⅠ HLA antigen was detected by serology and classⅡ HLA gene typing was performed by PCR-SSP method, thirty patients with EM were detected. Results The frequency of HLA-A30+31 and HLA-B13 antigen was significantly higher in EM patients than that in the controls(A30+31:Pc<0.01,RR=6.64;B13:Pc<10^-3,RR=7.88).The frequency of HLA-DQB1*04 gene was markedly higher in patients than that in the controls (DQB1*04: Pc<10^-3,RR=4.8125),while the frequency of DQB1*03 gene was significantly lower in EM patients than that in the controls(DQB1*03:Pc< 10^-5,RR=0.07). Conclusion There is a positive correlation between EM and HLA-A30+31、B13、DQB1*04,with a negative correlation between EM and HLA-DQB1*03.

Key words: Erythema multiforme, HLA antigens, Polymerase chain reaction