Abstract: Objective To study the clinical and histopathological features of subcutaneous panniculitis like T-cell lymphoma (SPTCL).Methods Twelve cases of SPTCL were investigated by clinicopathological and immunohistochemical methods.Results The ratio of male-to-female in this group was 1:1,and the median age was 26 years old The main clinical manifestations of SPTCL were asymptomatic plaques,nodules and masses Fever and weight loss were seen in three cases,and low level cell counts in routine blood test in 3 patients In seven followed up patients three died Histologically,patterns of lymphoid cell infiltration were lobular or diffuse panniculitis,or both The infiltrated lymphoid cells were of different size,irregular in shape,with few mitotic figures In tumor tissue,epithelioid granulomas,multinuclear giant cells(4/12),beanbag cells (7/12),small patches of necrosis(7/12),and tumor cell infiltrating small vessel walls (6/12)were observed CD45RO positive T-cells were shown in all 12 cases by immunohistochemical stain Conclusion s SPTCL has a specific clinicopathological picture,and the prognosis is poor in those with hemophagocytic syndrome or large tumor cells.

Key words: Skin neoplasms, Lymphoma,T-cell, Panniculitis