Abstract: Objective To investigate the relationship between endothelial cell injury and abnormality of coagulation and clinical manifestation in SLE patients by detection of plasma soluble thrombomodulin(sTM) Methods Levels of plasma soluble thrombomodulin in 40 SLE patients were determined by enzyme-linked immunosorbent assay (ELISA) Results 1 The plasma levels of sTM in 40 SLE patients were significantly higher than those in 20 controls,and they showed significant correlation with disease activity But no significant correlation was found between sTM levels and erythrocyte sedimetation rate,ANA,complement C3 levels;2 The plasma levels of plasma sTM in the patients with renal lesion were significantly higher than those without renal lesion,and there was a positive linear correlation between the sTM level and the quantity of 24 hour urine protein;3 there was a significant correlation between plasma sTM levels and fibrinogen(Fbg) or fibrinogen degradation product levels in SLE patients Conclusion There is injury of vascular endothelial cells in SLE patients,which is related to hypercoagulative state and low level of fibrinolytic function,and the determination of plasma sTM level may be used as an index in monitoring the disease activity and severity in SLE patients

Key words: Lupus erythematosus,systemic, Thrombomodulin