系统性红斑狼疮患者T淋巴细胞亚群Fas及bcl-2抗原的表达

Abstract

Abstract: Objective To study the expression of Fas and bcl-2 antigens on T lymphocyte subsets in patients with SLE and healthy controls.Methods Flow cytometry(two colour analysis) were used. Results We observed thatthe expression of Fas antigen on CD4⁺,CD8⁺,CD45RO⁺ T lymphocyte subsets of SLE patients was significantly higher than that of healthy controls(P<0.01) and thatthe expression of bcl-2 antigen was significantly decreased(P<0.01).Conclusion Increased expression of Fas antigen and decreased expression of bcl-2 antigen on T lymphocyte subsets may be related to the pathogenesis of SLE.

Key words: Lupus erythematosus,systemic, T lymphocyte subset, Fas, bcl-2

Jiang Li, Zhao Lijuan, He Chundi. Expression of Fas and bcl-2 Antigens on T Lymphocyte Subsets in Patients with Systemic Lupus Erythe-matosus[J].Chinese Journal of Dermatology, 1998, 31(1): 4-5.

[1]	. Modulation of T lymphocyte subsets and Fas/Fas ligand system in vitiligo patients by the combination of polysaccharide nucleic acid fraction of bacillus calmette guerin and a traditional Chinese medicine [J]. Chinese Journal of Dermatology, 2012, 45(6): 426-428.
[2]	. Acitretin inhibits the growth and induces the differentiation of mouse B16 melanoma [J]. Chinese Journal of Dermatology, 2009, 42(3): 193-196.
[3]	. Expression of fascin-1 protein in basal cell carcinoma and squamous cell carcinoma [J]. Chinese Journal of Dermatology, 2009, 42(2): 119-121.
[4]	. Overexpression of BAG-1 in human malignant melanoma and its association with p53 and bcl-2 [J]. Chinese Journal of Dermatology, 2008, 41(3): 180-.
[5]	JIN Xin, SONG Zhi-qi, WANG Ya-kun, XIAO Ting, CHEN Guang, JIANG Yi, CHEN Hong-duo, HE Chun-di. Bcl-2 regulates the Fas signaling pathway in the apoptosis of skin squarnous cell carcinoma cell line SCL-1 [J]. Chinese Journal of Dermatology, 2007, 40(7): 424-427.
[6]	YOU De-yuan, WANG Yan-dong, YOU Hai-yan. Immunohistochemical Study on Bcl-2 and PCNA in Mixed Tumor of Skin [J]. Chinese Journal of Dermatology, 2005, 38(5): 300-302.
[7]	ZENG Wen-jun, FAN Yi-ming, WU Zhi-hua. Peripheral Blood Lymphocytes Apoptosis and Expression of Fas and Bcl-2 in Patients with Secondary Syphilis [J]. Chinese Journal of Dermatology, 2005, 38(12): 725-728.
[8]	GAO Kui-bin, LI Ping, WANG Ya-kun, SONG Fang-ji, CHEN Hong-Duo. Expression of Caspase-3 and Bcl-xL in Lesional Skin of Patients with Psoriasis Vulgaris [J]. Chinese Journal of Dermatology, 2004, 37(10): 587-588.
[9]	DENG Liehua, ZHAO Gang, XIA Chaoyong. Quantitative Analysis of Bcl-2, Bax, Bcl-xl Expression in Basal Cell Carcinoma with Immunohistochemistry [J]. Chinese Journal of Dermatology, 2001, 34(3): 206-208.
[10]	GUO Zaipei, XIONG Lin, JIANG Xian. Relationship Between the Expression of bcl-2,Fas/FasL and the Apoptosis of Peripheral Lymphocytes in Patients with Systemic Lupus Erythematosus [J]. Chinese Journal of Dermatology, 2001, 30(1): 25-27.
[11]	NI Xiao, SUN Jianfang, ZENG Xuesi. Study on the Relationship Between c-myc, p53 and bcl-2 and Abnormal Apoptosis of Keratinocytes in Psoriatic Lesions [J]. Chinese Journal of Dermatology, 2000, 33(4): 240-242.
[12]	MAO Xiaohong, CHENG Hao, SUN Guojun. Evaluation of Cell Apoptosis in Lesional and Non-lesional Psoriatic Skin [J]. Chinese Journal of Dermatology, 2000, 33(2): 77-79.
[13]	MAO Xiaohong, CHENG Hao, SUN Cuojun. Immunohistochemical study of Epidermal and Dermal Expression of Bcl-X, Bcl-2 and Bax in Psoriasis [J]. Chinese Journal of Dermatology, 1999, 32(6): 383-385.
[14]	GENG Songmei, TAN Shengshun, LIU Enrang. Apoptosis Induced by Fas, FasL in the Pathogenesis of Psoriasis [J]. Chinese Journal of Dermatology, 1999, 32(2): 89-91.
[15]	XU Juan, ZHEN Maorong, FANG Yueming. Detection of Fas-L and Perforin in Psoriasis and Lichen Planus [J]. Chinese Journal of Dermatology, 1999, 32(2): 92-93.

Expression of Fas and bcl-2 Antigens on T Lymphocyte Subsets in Patients with Systemic Lupus Erythe-matosus

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10