Chinese Journal of Dermatology ›› 1998, Vol. 31 ›› Issue (1): 2-3.

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The Effect on Bone Mineral Density in SLE Patients After Long-term Administration of Tripterygium Wilfordii Hook F.

Huang Lan1, Feng Shufang1, Wang Hongfu2   

  1. Department of Dermatology, Huashan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1997-01-14 Revised:1997-10-05 Online:1998-02-15 Published:1998-02-15

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Abstract: Objective To investigate the effect on skeletal systemin SLE patients after long-termadministration of Tripterygium Wilfordii(TW). Methods The bone mineral density(BMD) of lumbar vertebrae 2～4 was detected by dual energy X-ray absorptiometry(DXA) with high sensitivity in 71SLE patients and healthy controls matched with age,sex,weight and height.Results (1) Long-termadminis-tration of TW could significantly decrease BMD level. (2) The degree of this effectwas significantly associ-ated with total duration of administration of TW. Conclusion Our data suggest that long-termadminis-tration of TW has remarkable effect on skeletal systemin SLE patients,and increases the risk rate of os-teoporosis and bone fracture.

Key words: Lupus erythematosis, systemic, Tripterygium Wilfordii, Bone mineral density