Abstract: Objective To study the relationship between antineutrophil cytoplasmic autoantibodies (ANCA) and anticardiolipin antibodies(ACA) and vascular injury in patients with SLE.Methods We examined ANCA/ACA in the sera from 99 patients with active SLE by indirect immunoflourescence technique and enzyme linked immunosorbent assay(ELISA) reapectively.Results The positive rate of ANCA in SLE patients with cutaneous vasculitic manifestation was 30.8% (12/39),and the positive rate in SLE patients without cutaneous vasculitis was 8.3% (5/60),the difference between the two groups was very significant (P<0.01). There was no significant difference in the positive rate of ACA between these two groups(P>0.05).These two kinds of antibodies were neither significantly correlated with renal involve-ment,arthritis,Raynaud’s phenomenon,nor with hypocomplementemia,antinuclear antibodies and anti-dsDNA antibodies.Conclusion ANCA detection may be useful to identify cutaneous vasculitis in SLE, but the value in the diagnosis of vasculitis of internal organs SLE needs to be further studied.

Key words: Lupus erythematosus, systemic, ANCA, ACA