Abstract: In order to avoid drug induced cutaneous photosensitivity, photohemolysis test was conducted to assess the phototoxicity of chlorpromazine in this study. The result showed that the hemolysis was induced by chlorpromazine after irradiation of UVA. The degree of hemolysis was correlated with the increasing of UVA dosage and chlorpromazine concentration, and chlorpromazine could not induce hemolysis without UVA irradiation. It suggests that this test system can be used to detect and monitor the phototoxic drugs.

Key words: Chlorpromazine, Ultraviolet ray, Photosensitivity disorders