Abstract: Protein kinase C(PKC) is a calcium.activated and phospholipid.dependant protein kinase. PKC is closely related to the cell proliferation and carcinogenesis. The activity of PKC in the cytoplasm and cell membrane of the epidermis of lesional skin and uninvolved skin of 15 patients with psoriasis and healthy persons was defermined respectively. The results showed that the specific activity (pmol/mg/min) of PKC was significantly higher (P<0.01) in the cytoplasm and cell membrane of the epidermis of involved and uninvolved skin of patients with psoriasis than that of in healthy persons. The results showed that there is translocation of PKC in psoriasis, and the pathogenesis of psoriasis is closely related with PKC activity.

Key words: Protein kinase C, Psoriasis