Abstract: A patient with basidiobolomycosis is reported,the clinical course described,the ultrastructural and histologic changes observed,and mycologic examination was made.The results indicated that:(1)In the course of using corticosteroids,because the inflammatory reaction was suppressed partially,the clinical manifestation was relatively relieved.In the loci the pathogenic fungi still grew well, and focal dissemination was observed;(2) In the course of using itraconazole,the drug exerted fungistatic and fungicidal action through the destruction of cell membranes of fungi.Meanwhile,itraconazole also exerted a synergistic action with the defense function of the human body,resulting in an enhanced therapeutic effects.The strong acute inflammatory reaction was triggered by the destroyed fungi caused by itraconazole.Then the fungi were cleared,the lesions were absorbed and repaired.Surgical intervention may be helpful to remove abscesses and fibrous nodules formed in the clinical course, so as to shorten the course of treatment.

Key words: Basidiobolomycosis, Basidiobolus, Itraconazole