银屑病患者HLA-DR基因分型的研究

Abstract

Abstract: HLA-DR gene frequency was obtained using polymerase chain reaction (PCR) and sequence-specific oligonucleotide (SSO) probes in 30 patients with psoriasis.Comparison of the HLA-DR gene frequency between the 30 patients and 255 normal controls showed that: HLA-DR7 gene frequency was significantly increased in the patients (25.0 vs 14.5,Pc<0.05,RR=2.446), while HLA-DR9 gene frequency was obviously decreased in the patients (3.33 vs 12.4, Pc<0.05,RR=0.218).The results showed that the psoriatic pathogenic gene might be closely related to the HLA-DR7 alleles.

Key words: Psoriasis, HLA antigens

Liu Shuwen, Li Hengjin, Chen Xiangmei. HLA-DR Genotyping Using Polymerase Chain Reaction and Sequence-Specific Oligonucleotide Probes in Patients with Psoriasis[J].Chinese Journal of Dermatology, 1995, 28(2): 80-82.

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HLA-DR Genotyping Using Polymerase Chain Reaction and Sequence-Specific Oligonucleotide Probes in Patients with Psoriasis

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