Abstract: Using ³H radioimmunoassy, the levels of leukotriene C₄ (LTC₄) were determined in 25 atopic dermatitis (AD) patients before and after the treatment of oral bovine spleen transfer factor (OBS-TF) and 33 normal controls. The results revealed that the seventy of AD presented a positive correlation with the level of LAC₄, and the levels of LTC₄ in both plasma and peripheral blood leukocytes (PBL)in AD were markedly higher than those of normal donors (P<0.001). The authors found that the OBS-TF could significantly reduce the levels of LTC₄ in both plasma and PBL, and significantly improve the symptoms and signs of AD. The results of our study indicated that LTC₄ may be involved in the pathogenetic process of AD as one of the strong inflammatory mediators, and OBS-TF may play an important role as an inhibitor of LTC₄ in AD.

Key words: Dermatitis,atopic, Leukotriene C₄, Transfer factor