Abstract: Wart lesions taken from 70 patients with three kinds of wart were studied by ASC-technique with monoclonal antibodies specific for T-cell aubscts, B-cell and HLA-DR antigen. Fxaept far a few lesions the epidersnai I2⁺ dendritic cells were reduced or absent in majority of iesions. Epidermal and dermal I2⁺ dendritic cells also showed ehauges in morphology, distribution and imtnunotype. These alterations may be caused by the direct cytotoxic effect of HPV. Keratinocytea in some regressing verruca vulgaris and plane warts expressed I2 antigen. The ratio of T4⁺/T8⁺ degassed significan内izt the dermal infilirates of three kinds of warts. The authors discus sed the different status of immunopathology, stressing the importazzcc of various types of HPY.