Chinese Journal of Dermatology ›› 1990, Vol. 23 ›› Issue (3): 161-162.

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1M NaCl (SODIUM CHLORIDE)SPLITSKIN AS A SUBSTRATE FOR THE DETECTION OF CIRCULATING IGA-ANTI-BASEMENT ZONE ANTIBODIES

SU Shi-Xiong1, R. P. HALL2   

  1. 1. Guangxi Medical Gollege, Nanning;
    2. Univcrsity Medical Center, U.S.A.
  • Received:1988-05-25 Revised:1989-10-30 Online:1990-06-15 Published:1990-06-15

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Abstract: The sera of 11 patients with linear IgA bullous dermatosia, 21 patients with dermatitis herpetiformis, 7 patients with bullous pemphi-goid and 12 normal subjects were examined for IgA-anti-basement membrane zone (BMZ) antibodies (Ab) using both 1M NaCl split normal human skin (NHS) and untreated NHS as substrate in indirect immunofluore-seance. This data suggests that 1M NaCl split NHS may be a more sensitive substrate than untreated NHS for the detection of IgA-anti-BMZ Ab.