Abstract: In this paper,5 specimens of skin lesion of patients with lupus erythematosus were lavestigated with immunotustochemical ABC method and imrmmocoiloidal gold method for the uitrastructural localizatians of the autoantibodies.It was found that IgG deposits located mainly in the lamina lucida and extended to the cell membrane of the basal eclls in some areas,and partially in the basal laanina and the dcrznis underneath.Besides,the importance of these findings to the diagnosis and further research was discussed.