Abstract: Anti-HTLV-Ⅰ and HTLV-Ⅲ antibodies were petected by using Western blot analysis in 58 cases of cutaueous T-cell lymphoma (CTLC) including 56 cases of mycosis fungoides (MF) and 2 cases of non-epirlermotropic CTCL,and 2 cases of cutaneous B cell lymphoma.The total positivity of the antibodies to HTLV was 26.7% (16/60).5%(3/60) of the case(among them CBCL 1 case) had anti-HTLV-Ⅰ p24 antibody,the other (18.3%) had mainly HTLV-Ⅲ p64 antibody.Except in one case of MF had both anti-HTLV-Ⅲ p64 and p41 antibodies,and other patients had only one anti-HTLV atxtibody.The results suggested that CTCL may have its own etiological virus and its antibody showed partial cross-reactivity with other HTLV virus.