Abstract: The determination of serum total IgE,IgE antinuclear antibodies (ANA) and lupus band test(LBT) for IgE are reported in 136 cases of SLE.SLE patients had higher serum IgE level (1922±2195IU/ml) than those of normals (P<0.001).IgE level of SLE patients in active phase was higher than that in remission phase (P<0.05).The positive rate of IgE ANA (35%) in the IgG ANA positive cases was higher than that iu the IgG ANA negative cases (P<0.05).The titer of IgE ANA was comparable to that of IgG ANA (r=0.922).Of them 2 IgG ANA negative cases was positive for IgE ANA,and it was helpful for the diagnosis.3 cases with positive IgE LBT of normal appearing akin in exposed area had active nephritis,hepatic abnormalities,positive nDNA antibody,thrombocytopenia and low serum complement C3.Their conditions were more aevcre than those of positive IgG or IgM LBT patients.