Abstract: Direct immunoHuorescence study was performed in 54 patients with alopecia areata and 16 healthy persons. Deposition of C₃, IgG or IgM was found in 46 patients (85%). There were three deposit patterns. The serum IgG value increased in some (12/54) patients. These observations suggest that immune disturbance is involved in the pathogenesis in most patients with alopecia areata.