Abstract: Eleven cases of cutaneous amyloidosis were investigated in this article immunohistochemically with monoclonal anti-keratin antibodies AE1, AE2 and AE3. The result showed that the amyloid substance in the papillary dermis of cutaneous amyloidosis was mostly AE1-and AE3-positive, and AE2-negative, indicating that the amyloid substance contained 50-kd/58-kd keratin pair which may have close relationship with basal cells because it is the only keratin pair in normal basal cells.