Chinese Journal of Dermatology ›› 1989, Vol. 22 ›› Issue (2): 95-96.

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THE INFLUENCE OF PBL OF PATIENTS WITH PSORIASIS ON THE IfERATINO-CYTES OF MOUSE

LIU Wei1, HU Chang-Fa2   

  1. Union Hospital, Tongji Medical University, Wuhan
  • Received:1987-10-05 Revised:1988-03-23 Online:1989-04-15 Published:1989-04-15

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Abstract: This article reports the effect of DNA syathesis of mouse epidermal cells cultured in the medium being previously cultured with PBL of patients with psoriasis.The results showed that the medium could stimulate mouse keruinocytes to synthesize DNA.The value of DNA synthesis of the mouse keratinocytes culture d in the medium was significantly higher than that of the control group.It seems likely that the soluble factor secreted by monocytes.It is suggested that the soluble factor secreted by psoriatic monocytes plays an important role in the pathogenesis of psoriasis.