Abstract: Very few studies on the expression of the surface antigen on Candida albicans with monoclonal antibodies have been reported, and no report about diagnosis of candidiasis using monaclonal antibodies is seen up to the present. Recently, by immunizing mice with whole cells of Candida albicans we produced an immunoglobulin M monoclonal antibody, designated E8H10, which recognized a cell surface antigen (probably mannan) on Candida albicans and cross-reacted with that on C. tropicalis and C. guilliermondii.