Abstract: In 257 cases of psoriasis, 10 parameters of serum levels of tyrosin; phenylalanine, mono-amine-oxidase, LDI-I, CPK, 5-nucleotidase and serotonin, the values of catacholamine (GA) including: norepinephrine anik epiztephrine, N-acetyl-β-aminoglycosidase in 24 hours urine were determined in this article, and these results were comparaed with those of the normal controls. All these data showed that there existed difFerent degrees of disturbances of the homeostasis in psoriatics except the values of CPK, phenylalanine and epinephrine. So authers suggest that the pathologic courses of psoriasis do not limited in the epidermis and dermis only, but have some changes of the homeostasis.