Abstract: Sodium pyrithone is a broad spectrum antimycotic drug.It is a sodium salt of 2-mercaptopyridine-N-oxide. In vitro test, it showed variable mycostatic action on 17 mpcotic strains. The MIC of the drug on Trichophyton rubrum, Epidermophyton floccosum and Trichophyton gypseum was lower than that of Econazole. One hundred and three cases of dermatomycoses were treated with sodium pyrithone, 30 cases(87.38%)were cured. The a study comparing 1% sodium pyrithone cream with 1% sodium pyrithone solution(50% alcohol),the result showed no significant difference(P>0.05).