Abstract: A freeze-etching study of plasma membrane in psoriatic epidermis has demonstrated an increase of membrane associated particles (map) and the number of gap junctions (GJ),dilatation of intercellular space. But after treatment with Antipsoriatic prescription (No.3),it revealed a significant decrease of map and GJ. The intercellular space became normal. All these suggested the activity of cells and increasing membrane protein were suppressed by the Chinese medicinal herbs. Besides, the changes of glycoprotein surface coats and the ability of GJ production were probably influenced.