Abstract: Fifty-eight patients with SLE were investigaled on five parameters(Fbg,FDP,PT,KPTT,ELT) of the coagulation-fibrinolysis,and the clinical significance of these:parameters was discussed.The hypercoagulative state aad the enhancement of the compensatory fibrinolysis in various degrees existed in the SLE patients.The former might be related to the lesions in different viscera,especially to those in the kidneys.