Abstract: Skin lesions from 6 patients with psoriasis in different stages were studied with EM. The lesions Taken before and after treatment in three cases and the uninvolved skin in two cases were observed. Results: Epidermal cells of different layers showed abnormal changes, The number df intercellular desmosomes diminished, and intercellular spaces widened, There was.inflammatory infiltration of neutrophils and lymphocytes in the intercellular spaces of prikle cells, Individual nuclei of prikle cells remained larger and intercellular space slightly wider after clearing of the lesions clinically, In the uninvolved areas. mitochondria were found aggregated within prikle cells and the intercellular spaces widened.