Abstract: Gamma Benzene Hexachloride (γ-666) is acaricide, 454 cases of scabies were treated with 1% γ-666 cream produced by the Guangzhou 6th Pharmaceutical Factory. The cream was applied all over the body surface in a thin film with preliminary bathing. The film was left for 24 hours and the patient then took a bath. 420 cases(92.51%) were cured. 196 cases of scabies were treated with 10% sulphur ointment, The application was repeated in,successive evenings. 184 cases(93.88%)were cured, Comparing 1% γ-666 cream with 10% sulphur ointment, the difference of their effects was not significant. (P>0.05).Another group of 30 cases of scabies were treated with 1% γ-666 cream and a second application was made on the following week. All were cured. Skin test with γ-666 cream showed no irritation to the skin. Liver function test and routine tests of blood and-urine of the patients after treatment showed no abnormalities. The authors suggest that γ-666 cream is a valuable preparation for treating scabies.