Abstract: 52 cases of psoriasis vulgaris within one year duration were treated with Warfarin, Results showed:the total rate of effectiveness was 84.8%,with marked effective rate of 63.46%,and clinical cure rate of 36. 54%.Comparing with groups receiving aminopterin or placebo, the Warfarin group showed the advantages of negligible side effects (1.92%). prolonged regressive period, and low recurrence rate.The authors considered that Warfarin might be effective through the improvement of microcirculation.