Chinese Journal of Dermatology ›› 2019, Vol. 52 ›› Issue (9): 636-639.doi: 10.3760/cma.j.issn.0412-4030.2019.09.009

• Research Reports • Previous Articles     Next Articles

Value of dermoscopy in differential diagnosis of extramammary Paget′s disease and chronic eczema of the vulva

Zhang Wei1, Huang Liming2, Nie Jin3, Wu Minzhi4, He Fanghua4, Lu Xinfeng5, Wang Yan2, Shao Xuebao1, Li Jingjing4, Mo Xingfan4, Zhao Liang2, Sun Jianfang1   

  1. 1Department of Pathology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 2Department of Dermatologic Surgery, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 3Clinical Pharmacology and Cosmetics Testing Center, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 4Department of Dermatology and Venereology, The Fifth People′s Hospital of Suzhou, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou 215131, China; 5Department of Dermatology and Venereology, Jingjiang People′s Hospital, Jingjiang 214500, Jiangsu, China
  • Received:2018-07-09 Revised:2019-02-19 Online:2019-09-15 Published:2019-08-30
  • Contact: Zhao Liang; Sun Jianfang E-mail:zhaoliang210042@hotmail.com; fangmin5758@aliyun.com
  • Supported by:
    Scientific Research Project of Jiangsu Commission of Health （BJ16007）; The Introduction Project of Clinical Expert Team in Suzhou （SZYJTD201811）; CAMS Innovation Fund for Medical Sciences （CIFMS-2017-I2M-1-017）; Rare and Genetic Skin Diseases Research Fund of Chinese Dermatologist Association （2018）

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Abstract: 【Abstract】 Objective To describe the dermoscopic features of extramammary Paget′s disease （EMPD） and chronic eczema of the vulva, and to explore the value of dermoscopy in the diagnosis and differential diagnosis of the above diseases. Methods Dermoscopic images were collected from 20 patients with histopathologically confirmed vulvar EMPD and 16 patients with clinically confirmed chronic eczema of the vulva in Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Pekin Union Medical College from January 2017 to April 2018, and retrospectively analyzed. Fisher′s exact test was used to compare the prevalence of dermoscopic features between the two groups. Results As dermoscopy showed, the milky red background was observed in 19 EMPD patients and in only 1 patient with chronic eczema, and there was a significant difference in the prevalence of milky red background between the two groups （P < 0.001）. White scales were the most common desquamation, and were observed in 9 EMPD patients and 13 patients with chronic eczema （P = 0.128）. Blood vessels were uniformly distributed in EMPD patients, including dotted-globular vessels in 19 and linear vessels in 14 , while blood vessels were distributed in a patchy or clustered pattern in the patients with chronic eczema, including dotted-globular vessels in 16 and linear vessels in 7. There was a significant difference in the prevalence of different distribution patterns of blood vessels between the two groups （P < 0.001）. Bright white streaks, bright white structureless area and reticular structure were observed in 19, 20 and 19 EMPD patients respectively, and in 1, 1 and 1 patient with chronic eczema respectively, and there were significant differences in the prevalence of the above 3 structures between the two diseases （all P < 0.001）. Conclusion Vulvar EMPD and chronic eczema both show characteristic dermoscopic features, and dermoscopy is of great value to the diagnosis and differential diagnosis of EMPD.

Key words: Paget disease, extramammary, Dermoscopy, Eczema