Chinese Journal of Dermatology ›› 2019, Vol. 52 ›› Issue (1): 50-52.doi: 10.3760/cma.j.issn.0412-4030.2019.01.017

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BP180-related autoimmune blistering diseases

Li Suo, Feng Suying   

  1. Department of Dermatology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China
  • Received:2018-06-04 Revised:2018-07-24 Online:2019-01-02 Published:2019-01-02
  • Contact: Feng Suying E-mail:fengsy@pumcderm.cams.cn
  • Supported by:
    CAMS Innovation Fund for Medical Sciences (CIFMS?2017?I2M?1?017)

     

Abstract: BP180-related autoimmune blistering diseases include bullous pemphigoid, lichen planus pemphigoides, linear IgA bullous dermatosis, pemphigoid gestationis and cicatricial pemphigoid. There are multiple autoantibody-reactive sites on the extracellular region of BP180. Current studies show that there is heterogeneity in the autoimmune blistering disease-related target sites on BP180, and different clinical manifestations of the same disease are related to the heterogeneity of target sites. However, further studies and analysis are still needed for the mechanism of the heterogeneity.

Key words: Pemphigoid, bullous, Pemphigoid gestationis, Pemphigoid, benign mucous membrane, Linear IgA bullous dermatosis, BP180