Abstract: 【Abstract】 Eruptive melanocytic nevi is a rare disease. This article reports two cases for the first time in China. Case 1 is an 8-year-old boy who has developed numerous black rashes on his face and trunk for 1 year. The patient had acute B-cell leukemia and received allogeneic hematopoietic stem cell transplantation. Olverembatinib was started 3 months before the onset of rash. Case 2 is a 6-year-old boy who has developed numerous black rashes on his face and trunk for 10 months. The patient had acute B-cell leukemia and received allogeneic hematopoietic stem cell transplantation. He had been using methotrexate, mycophenolate mofetil, cyclosporine, ruxolitinib, etc. within 6 months before the appearance of the rash. Dermoscopy and pathology confirmed that the newly developed rash on the hand was a melanocytic nevus. Currently, both patients have stopped taking the relevant medications. In case 1, some of the small rashes are gradually fading in color and even subsiding. In case 2, the rashes have not significantly increased in number but are still slowly enlarging.

Key words: Nevus, pigmented, Eruptive, Olverembatinib, Immunosuppressive agents, Leukemia