伴难治性嗜中性脂膜炎的VEXAS综合征1例

doi:10.35541/cjd.20240116

Chinese Journal of Dermatology ›› 2026, e20240116.doi: 10.35541/cjd.20240116

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A case of VEXAS syndrome with refractory neutrophilic panniculitis

Sun Jinghui¹, Yan Min1, Wang Hui², Wang Tingting³, Xu Mengting¹, Xing Jian⁴, Chen Hao⁵

¹Department of Dermatology, Shengli Oilfield Central Hospital, Dongying 257034, China; ²Department of Pathology, Shengli Oilfield Central Hospital, Dongying 257034, China; ³Department of Clinical Laboratory, Shengli Oilfield Central Hospital, Dongying 257034, China; ⁴Department of Hematology, Shengli Oilfield Central Hospital, Dongying 257034, China; ⁵Department of Pathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Nanjing 210042, China

Received:2024-03-01 Revised:2025-04-12 Online:2026-03-11 Published:2026-07-17
Contact: Chen Hao; Xing Jian E-mail:ch76ch@163.com; sddyxingjian@163.com DOI: 10.35541/cjd.20240116

Abstract

Sun Jinghui, Yan Min, Wang Hui, Wang Tingting, Xu Mengting, Xing Jian, Chen Hao. A case of VEXAS syndrome with refractory neutrophilic panniculitis[J]. Chinese Journal of Dermatology,2026,e20240116. doi:10.35541/cjd.20240116

References ［6］

［1］	杨晓曦, 李朝晖, 赵丹青, 等. VEXAS综合征1例. 中华医学杂志, 2023,103（1）:46⁃48. DOI: 10.3760/cma.j.cn112137⁃20221107⁃02345.
［2］	Beck DB, Bodian DL, Shah V, et al. Estimated prevalence and clinical manifestations of UBA1 variants associated with VEXAS syndrome in a clinical population［J］. JAMA, 2023,329（4）:318⁃324. DOI: 10.1001/jama.2022.24836.
［3］	Grayson PC, Patel BA, Young NS. VEXAS syndrome［J］. Blood, 2021,137（26）:3591⁃3594. DOI: 10.1182/blood.2021011455.
［4］	Collins JC, Magaziner SJ, English M, et al. Shared and distinct mechanisms of UBA1 inactivation across different diseases［J］. EMBO J, 2024,43（10）:1919⁃1946. DOI: 10.1038/s44318⁃024⁃00046⁃z.
［5］	Kosmider O, Possémé C, Templé M, et al. VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation［J］. Nat Commun, 2024,15（1）:910. DOI: 10.1038/s41467⁃024⁃44811⁃4.
［6］	Mekinian AM, Georgin⁃Lavaille S, Ferrada MA, et al. American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS developed by the International VEXAS Working Group Expert Panel［J/OL］. Arthritis Rheumatol，2025［2025⁃08⁃15］. DOI: 10.1002/art.43287. https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43287.

A case of VEXAS syndrome with refractory neutrophilic panniculitis

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