Abstract: 【Abstract】 Objective To investigate clinical efficacy of mucopolysaccharide polysulfate cream combined with sertaconazole nitrate cream in the treatment of scaly hyperkeratotic tinea pedis. Methods From March 2019 to January 2020, 100 patients with scaly hyperkeratotic tinea pedis were enrolled into this study, and randomly and equally divided into 2 groups by using a random number table: control group treated with topical sertaconazole nitrate cream alone at a dose of 0.5 - 1 g twice a day; combined group treated with topical mucopolysaccharide polysulfate cream at a dose of 0.5 - 1 g followed by topical sertaconazole nitrate cream at a dose of 0.5 - 1 g 30 minutes later, which were performed twice a day. The treatment lasted 4 weeks. The time to clinical symptom relief, efficacy and incidence of adverse reactions were compared between the two groups. Dermatological life quality index （DLQI） was assessed at 0, 2 and 4 weeks after the start of treatment. Two-independent-sample t test, repeated measures analysis of variance and chi-square test were used for statistical analysis. Results After 4-week treatment, the time to pruritus relief and that to desquamation improvement were 6.05 ± 1.98 and 12.03 ± 3.92 days respectively in the combined group, which were significantly shorter than those in the control group （8.39 ± 2.11, 15.11 ± 4.05 days, t = 5.72, 3.86, respectively, both P < 0.001）. During the 4 weeks of treatment, DLQI scores gradually decreased in both the 2 groups （all P < 0.001）, which were significantly lower in the combined group than in the control group at weeks 2 and 4 （both P < 0.001）. After 4-week treatment, the total response rate was 98% （49/50） in the combined group, significantly higher than that in the control group （82%, 41/50; χ2 = 7.11, P = 0.007）. There was no significant difference in the incidence of adverse reactions between the two groups （P > 0.05）. Conclusion Mucopolysaccharide polysulfate cream can improve the efficacy of sertaconazole nitrate cream in the treatment of scaly hyperkeratotic tinea pedis.

Key words: Tinea pedis, Scaly hyperkeratotic tinea pedis, Mucopolysaccharide polysulfate cream, Sertaconazole nitrate cream