Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (10): 922-924.doi: 10.35541/cjd.20200493

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Nonbullous pemphigoid

Shan Ying1,2, Chang Xiaotong2, Zuo Yagang1   

  1. 1Department of Dermatology, National Clinical Research Center for Skin and Immune Diseases, Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; 2Hebei North University, Zhangjiakou 075000, Hebei, China
  • Received:2020-05-20 Revised:2021-01-11 Online:2022-10-15 Published:2022-10-08
  • Contact: Zuo Yagang
  • Supported by:
    National Natural Science Foundation of China (81972944); Natural Science Foundation of Beijing Municipality (7192166)

Abstract: 【Abstract】 Nonbullous pemphigoid (NBP), which is related to bullous pemphigoid, has various clinical manifestations, and is frequently accompanied by itching. Typical clinical manifestations of bullous pemphigoid (BP), such as tense blisters or bullae, are absent in NBP cases. It is easy to misdiagnose. Histopathological findings are not specific, so diagnosis should be confirmed by direct immunofluorescence, indirect immunofluorescence or salt-split indirect immunofluorescence. NBP may develop into BP in some cases, and the prognosis of NBP is better than that of BP. However, delayed diagnosis usually leads to a relatively high dosage of drugs for disease control, and a high rate of adverse reactions.

Key words: Pemphigoid, bullous, Fluorescent antibody technique, Nonbullous pemphigoid, Prodromal pemphigoid