Abstract: 【Abstract】 Lamotrigine is a new type of drug for the treatment of epilepsy, bipolar disorder and neuralgia. Drug eruption is the common adverse reaction to lamotrigine, such as fixed drug eruption, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome, etc. The pathogenesis of lamotrigine-induced drug eruptions includes immune and non-immune mechanisms. HLA alleles are related to drug eruptions caused by lamotrigine, and their relationship differs among different races and type of drug eruptions. This review summarizes the etiology, pathogenesis and clinical characteristics of drug eruptions caused by lamotrigine, aiming to guide clinical treatment.

Key words: Drug eruptions, HLA antigens, Lamotrigine