中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (5): 285-287.

• 论著 • 上一篇    下一篇

特应性疾病中性粒细胞酶的研究

薛筑云, 吕湘琴, 余美玲   

  1. 南京医学院第一附属医院皮肤科, 210029
  • 收稿日期:1992-08-05 修回日期:1992-12-26 出版日期:1993-10-15 发布日期:1993-10-15
  • 基金资助:
    国家自然科学基金资助裸题

Study of Neutrophii Enzymes in Atopic Diseases

XUE Zhu-Yun   

  1. The First Affiliated Hospital, Nanjing Medical College, Nanjing 210029
  • Received:1992-08-05 Revised:1992-12-26 Online:1993-10-15 Published:1993-10-15

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摘要： 研究20例特应性疾病.8例患者的双亲及10例正常人中性粒细胞(PMN)光镜细胞化学结果:全部患者髓过级化物酶(MPO)和酸性磷酸醉(ACP)活性显奢降低.两者无线性相关.碱性磷酸醉活性正常.7/8例的双亲或其一方PMN有类似缺陷.结果表明:特应性疾病中PbiN嗜天青颗粒的MPO和ACP有原发性、联合性和部分性缺陷.推测该缺陷导致PMN杀菌力降低和杀菌延缓;异物降解不全.形成抗原特性.成为特应性疾病中感染倾向和敏感抗原形成的重要细胞生物学基础.

关键词: 中性粒细胞, 髓过氧化酶类, 磷酸一酷酶类, 特应性疾病

Abstract: The neutxophils (PMN) from 24 cases of atopic diseases,the parents of 8 cases and 10 normal controls were studied by light-mictoscopic cytochemisty.The results revealaed that myeloperoxidase (MPO) and acid phosph atase (ACP) activities for all cases signzfica}tly decreased,no linear correlation was found between MPO and ACP; alkaline phosphatase activity was normal.The neutrophils from 7 cases' parents or parent revealed similar deficiency to thatCrom the patients.The results indicated that a combined and partial primary defiuency of MPO and ACP of PMN azurophilic gran ules eristed in the patients with atopic diseases.Presumably,the deficiency leads to lower PMN bactericidal ability and bactericidal delay; foreign bodies are degraded partially and tunred to be antigenic,and thus become an important cytobiological basis of susceptibility to infections and formation so sensitive antigen in atopic diseases.

Key words: Neutroghil Myeloperoxidase, Phosphornonoes terases, Atopic disease