中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (4): 226-227.

• 论著 • 上一篇    下一篇

白癜风抗原的辨认

谢忠, 季素珍, 沈丽玉, 朱学骏   

  1. 北京医科大学第一医院皮肤科 100034
  • 收稿日期:1994-09-07 修回日期:1995-01-14 出版日期:1995-08-15 发布日期:1995-08-15

Identification of Vitiligo Antigens

Xie Zhong, Ji Suzhen, Shen Liyu   

  1. Department of Dermatology, The First Teaching Hospital, Beijing Medical University, Beijing 100034
  • Received:1994-09-07 Revised:1995-01-14 Online:1995-08-15 Published:1995-08-15

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摘要： 采用黑素细胞培养技术、免疫电泳和免疫印迹技术检测了48例白癜风患者的血清,研究发现,52%的白癜风患者血清中存在抗黑素细胞的抗体,抗体可对应一个或几个抗原,分子量约75000、90000、110000、150000。研究表明,抗黑素细胞抗体与白癜风的发病有关,这些抗体可能针对黑素细胞表面的抗原。

关键词: 白癜风, 抗原, 黑素细胞

Abstract: It is known that patients with vitiligo often have antibodies to melanocytes. In order to identify vitiligo antibodies react to corresponding antigens, we used cultured normal human melanocytes to react with sera from 48 patients with vitiligo, the result showed that 52% of patients with vitiligo have antibodies to cell-surface antigens of melanocytes. Then immunoprecipitation and SDS-PAGE analysis were used to reveal molecular weights (MW) of the antigens, the result showed that the MW are about 75 000, 90 000, 110 000, and 150 000.

Key words: Vitiligo, Antigens, melanocytes, Melanocytes