中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (6): 340-341.

• 论著 • 上一篇    下一篇

咪唑斯汀治疗6970例慢性荨麻疹临床研究

余碧娥, 廖康煌, 皿治林治疗荨麻疹全国多中心临床协作组   

  1. 上海复旦大学附属华山医院皮肤科 200040
  • 收稿日期:2002-04-02 出版日期:2003-06-15 发布日期:2003-06-15

Therapeutic Effect of Mizolastine in the Treatment of 6970 Patients with Chronic Urticaria

YU bi-e, LIAO Kang-huang   

  1. Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2002-04-02 Online:2003-06-15 Published:2003-06-15

PDF (PC)

55

赞

摘要： 目的 观察咪唑斯汀治疗慢性荨麻疹的疗效和安全性。方法 口服咪唑斯汀10mg,每日1次,连服14d为1个疗程。结果 用咪唑斯汀治疗6970例慢性荨麻疹患者,总有效率治疗7d为49.0%,14d达85.0%。治疗后患者的瘙痒、风团大小和数量均有明显改善,治疗7d和14d时分别与治疗前比较,治疗14d时与治疗7d时比较,差异均有非常显著性(P<0.001)。治疗1d后半数患者的症状和体征开始缓解,3d后80%以上出现改善。不良反应少,主要表现为困倦(6.8%,与一般安慰剂的发生率相同)和头晕(1.4%)。结论 咪唑斯汀治疗慢性荨麻疹有效而安全。

关键词: 荨麻疹, 组胺H1拮抗剂

Abstract: Objective To study the efficacy and safety of mizolastine in the treatment of chronic urticaria.Methods With oral mizolastine,10mg daily,all patients received14days treatment as a course.Results The total effective rate of 49.0% were found in7days,and 85.0% in 14 days after initiation of treatment with mizolastine in 6970 chronic urticaria patients.The improvement of itching and wheals,after 7 days and14days treatment,was significantly higher than before treatment,respectively(P<0.001).It was found that half of the patients improved after1d treatment,and 80% patients improved after 3 days.Adverse reactions were mild,mainly sleepiness(6.8%,similar to placebo)and dizziness(1.4%).Conclusion Mizolastine is an effective and safe drug in treating chronic urticaria.

Key words: Urticaria, Histamine antagonists