中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (6): 338-339.

• 论著 • 上一篇    下一篇

女性更年期痤疮患者的临床特征及睾酮和雌二醇水平的检测

王建琴1, 龙邵萌2, 曾仁山1, 唐韶生1, 杨捷1, 吴江1   

  1. 1. 广州市第一人民医院皮肤科 510180;
    2. 广东省水电二局职工医院皮肤科
  • 收稿日期:2002-04-27 出版日期:2003-06-15 发布日期:2003-06-15

Serum Level of Testosterone and Estradiol,and Clinical Features in Female Patients with Climacteric Acne

WANG Jian-qin1, LONG Shao-meng2, ZENG Ren-shan1, TANG Shao-sheng1, YANG Jie1, WU Jiang1   

  1. Department of Dermatology, First Municipal People's Hospital of Guangzhou, Guangzhou 510180, China
  • Received:2002-04-27 Online:2003-06-15 Published:2003-06-15

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摘要： 目的 探讨女性更年期痤疮患者血清性激素水平的变化,临床特征及治疗方法。方法 对66例患者的临床特征及治疗进行了观察;测定其中35例患者的血清睾酮和雌二醇水平。结果 患者睾酮、雌二醇与正常人对照组相比较差异无显著性,但睾酮/雌二醇显著高于正常人对照组(P<0.05)。63.6%的患者在更年期发病。皮损以上唇及颏部最多,其次为颊部、额部,多呈散在分布,以粉刺及炎性丘疹或丘脓疱疹为主,少数有炎性结节。多为轻至中度痤疮。78.8%的患者一般治疗即可治愈,其余患者用性激素治愈。结论 更年期因卵巢功能衰退,雌激素分泌减少,雌雄激素比例失衡,肾上腺源性雄激素相对过甚而导致痤疮。更年期痤疮多为轻至中度,皮损以粉刺、炎性丘疹或丘脓疱疹为主,以上唇及颏部最多。绝大多数患者一般治疗即可治愈。

关键词: 痤疮, 寻常, 睾酮, 雌二醇

Abstract: Objective To investigate serum levels of sex hormones,clinical features and therapeutic regimen in women with climacteric acne.Methods The characteristics of skin lesions and therapeutic effect were observed in 66 female patients with climacteric acne.The serum levels of testosterone,and estradiol were measured with radioimmunoassay in 35 patients.Results No significant difference was found in the serum levels of testosterone and estradiol between the patients and normal controls(P>0.05),but the ratio of testosterone/estradiol was significantly higher in patients than that of the controls(P<0.05).The clinical features were as follows:(1)The lesions started in climacteric period in 63.6% cases.(2)Most lesions scattered around mouth and chin,then on the cheek and frontal part.(3)The acne was mild to moderate in severity,consisting mainly of comedones and inflammatory lesions(papules and papulopustules).(4)78.8% climacteric acne patients were cured with ordinary therapy,the others with sex hormone therapy.Conclusions The ratio of estrogen and androgen is unbalanced,and the level of adrenal androgens is relatively increased in climacteric acne patients.Most cases are mild to moderate in severity,most patients can be cured with ordinary therapy.

Key words: Acne vulgaris, Testosterone, Estradiol